How J, Davidson R J, Bewsher P D
Scand J Haematol. 1979 Oct;23(4):323-8. doi: 10.1111/j.1600-0609.1979.tb02869.x.
The Coulter 'S' red cell profile was studied prospectively in 100 untreated non-anaemic hyperthyroid patients and followed up in 52 of them until they had become euthyroid with radio-iodine or carbimazole treatment. Serial haematological data were also obtained in 23 hyperthyroid patients during treatment with beta-adrenoreceptor blocking drug alone. The most significant finding was a low mean corpuscular volume (MCV) which was invariably present throughout the hyperthyroid state. Treatment with beta-adrenoreceptor blocking drugs did not significantly alter any of the red cell parameters. On the other hand, the MCV increased and was restored to normal with radio-iodine or carbimazole treatment although there was a lag period of about 6--8 weeks between achieving the euthyroid state and the normalisation of this red cell index. While none of the patients were aneaemic, the haemoglobin level rose significantly following effective anti-thyroid treatment. It is suggested that measurement of the MCV may have a useful role in the diagnosis of hyperthyroidism. 2 possible mechanisms leading to the observed red cell changes in hyperthyroidism are postulated.
对100例未经治疗的非贫血性甲状腺功能亢进患者的库尔特“S”红细胞图谱进行了前瞻性研究，并对其中52例患者进行了随访，直至他们通过放射性碘或卡比马唑治疗恢复正常甲状腺功能。还对23例甲状腺功能亢进患者在单独使用β-肾上腺素能受体阻滞剂治疗期间进行了系列血液学数据采集。最显著的发现是平均红细胞体积（MCV）降低，在整个甲状腺功能亢进状态下始终存在。使用β-肾上腺素能受体阻滞剂治疗并未显著改变任何红细胞参数。另一方面，尽管在达到正常甲状腺功能状态与该红细胞指数恢复正常之间存在约6-8周的延迟期，但放射性碘或卡比马唑治疗后MCV升高并恢复正常。虽然没有患者贫血，但有效抗甲状腺治疗后血红蛋白水平显著升高。提示MCV测量可能在甲状腺功能亢进的诊断中具有有用作用。推测了导致甲状腺功能亢进中观察到的红细胞变化的2种可能机制。
