18-取代甾体。第4部分。3α,18,21-三羟基-5β-孕烷-20-酮18,20-半缩醛（18-羟基四氢脱氧皮质酮）的化学合成
18-substituted steroids. Part 4. A chemical synthesis of 3 alpha,18,21-trihydroxy-5 beta-pregnan-20-one 18--20-hemiacetal (18-hydroxy-tetrahydro-DOC).
作者信息
Hossain M, Kirk D N
出版信息
Steroids. 1979;34(6 Spec no):677-81. doi: 10.1016/0039-128x(79)90137-5.
PMID:538774
Abstract
3 alpha,18,21-Trihydroxy-5 beta-pregnan-20-one 18 leads to 20-hemiacetal (18-hydroxy-tetrahydro-DOC) has been prepared from 3 alpha-acetoxy-5 beta-pregnan-20-one by reduction to the 20 beta-alcohol, application of the 'hypoiodite' reaction [Pb(OAc)4-I2-hv] with subsequent steps leading to the 18-hydroxy-20-ketone (as hemiacetal), and C-21 acetoxylation [Pb(OAc)4] followed by hydrolysis.
摘要
由3α-乙酰氧基-5β-孕甾-20-酮经还原为20β-醇，应用“次碘酸盐”反应[四乙酸铅-碘-光照]，随后经过一系列步骤得到18-羟基-20-酮（以半缩醛形式），再进行C-21乙酰氧基化[四乙酸铅]然后水解，制备出了3α,18,21-三羟基-5β-孕甾-20-酮18,20-半缩醛（18-羟基-四氢脱氧皮质酮）。
Zotero 插件