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[大鼠异戊二烯肾上腺素治疗心肌的比较、定量和形态学研究(自动图像分析——微观形态计量分析)(作者译)]

[Comparative, quantitative and morphological investigations (automatic image analysis--micromorphometric analysis) of myocardium of rat isoprenalin treatment (author's transl)].

作者信息

Piera O, Meyer R, Voss K, Wenzelides K

出版信息

Zentralbl Allg Pathol. 1979;123(6):590-3.

PMID:539175
Abstract

The alterations of areas of myocardium of male rats (2, 4, and 6 months) are investigated after isoprenalin treatment (0.05 mg/kg body weight and day i.p. for 30 days). The investigations are carried out using automatic microscope picture analysis, morphometric point counting and resp. Both methods yield the same qualitative results: The effect of isoprenalin is dependent on age and yields for old rats (6 months) only very little morphometric alterations in the myocardium. The automatic microscope picture analysis is a very effective method of investigation (45 seconds/cross section).

摘要

研究了用异戊二烯肾上腺素(0.05毫克/千克体重,腹腔注射,每天一次,共30天)处理后雄性大鼠(2个月、4个月和6个月)心肌区域的变化。使用自动显微镜图像分析、形态计量点计数等方法进行研究。两种方法得出相同的定性结果:异戊二烯肾上腺素的作用取决于年龄,对老年大鼠(6个月)而言,心肌的形态计量学变化非常小。自动显微镜图像分析是一种非常有效的研究方法(每个横截面45秒)。

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