乙醇对人血小板5-羟色胺（血清素）体外摄取的抑制作用。

Inhibitory effect of ethanol on 5-hydroxytryptamine (serotonin) uptake in human blood platelets in vitro.

作者信息

Lingjaerde O

出版信息

Acta Pharmacol Toxicol (Copenh). 1979 Nov;45(5):394-8. doi: 10.1111/j.1600-0773.1979.tb02407.x.

DOI:10.1111/j.1600-0773.1979.tb02407.x

Abstract

Ethanol in concentrations higher than 10(-2) M (or about 0.5% W/W) inhibited the uptake of 14C-5-hydroxytryptamine (serotonin) in human blood platelets in an artificial, protein-free medium, by a non-competitive mechanism. The inhibition was not influenced by the alcohol dehydrogenase inhibitor methylpyrazole (10(-3) M). In concentrations up to 0.1 M, ethanol had no effect on 5-HT efflux from the platelets. At higher concentrations, ethanol increased efflux. Inhibition of 5-HT uptake was found to increase progressively in the sequence methanol - ethanol - propanol - butanol.

摘要

浓度高于10⁻² M（或约0.5% W/W）的乙醇，在无蛋白质的人工培养基中，通过非竞争性机制抑制人血小板对¹⁴C - 5 - 羟色胺（血清素）的摄取。这种抑制不受乙醇脱氢酶抑制剂甲基吡唑（10⁻³ M）的影响。浓度高达0.1 M时，乙醇对血小板中5 - 羟色胺（5 - HT）的流出没有影响。在更高浓度下，乙醇会增加流出。研究发现，5 - HT摄取的抑制作用在甲醇 - 乙醇 - 丙醇 - 丁醇序列中逐渐增强。