Marsh W L, Oyen R, Alicea E, Linter M, Horton S
Am J Hematol. 1979;7(2):155-62. doi: 10.1002/ajh.2830070208.
Approximately one in 250 people with autoimmunity involving their red cells have IgG autoantibodies with specificity in the Kell blood groups. Red cells of these individuals have an acquired temporary weakening of their Kell antigens. Some of the patients also have allo-anti-K in their serum. This report presents a case in which an IgG autoantibody may define a new high-incidence red cell antigen related to the Kell blood groups. The patient's Kell blood group antigens are depressed, and his serum contains allo-anti-K. It is postulated that reduced red cell Kell antigenicity is caused by enzymatic degradation, possibly of bacterial origin, and that the acquired loss of Kell antigens, the Kell-specific autoimmune state, and the serum all0-anti-K, are all related aspects of one phenomenon.
每250名患有涉及红细胞自身免疫性疾病的人中，约有1人具有针对凯尔血型系统的IgG自身抗体。这些个体的红细胞会出现凯尔抗原获得性暂时减弱。部分患者血清中还存在同种抗-K。本报告介绍了一例病例，其中一种IgG自身抗体可能定义了一种与凯尔血型系统相关的新型高发生率红细胞抗原。该患者的凯尔血型抗原降低，其血清中含有同种抗-K。据推测，红细胞凯尔抗原性降低是由酶促降解引起的，可能源于细菌，并且凯尔抗原的获得性丧失、凯尔特异性自身免疫状态以及血清同种抗-K都是同一现象的相关方面。
