Loirat C, Pillion G, Schlegel N, Douenias R, Mathieu H
Arch Fr Pediatr. 1979 Nov;36(9 Suppl):LVI-LXIII.
The main coagulation and fibrinolysis proteins have been studied in 22 children with nephrotic syndrome. Some anomalies such as the increase of fibrinogen and of Factors II, V, VII + X concentrations and the decrease of antithrombin III concentration could induce an hypercoagulability. Other anomalies such as the high alpha 2 macroglobulin concentration and the frequently low plasminogen concentrations could induce a decrease of the plasma fibrinolytic activity. The consequences of the low alpha 1 antitrypsin levels are probably less important. The fast alpha 2 antiplasmin levels have been found variable in the different patients. Practically, it appears that most children with plasma albumin levels less than 15-17 g/l have antithrombin III levels less than 23 mg/dl (70% of normal), which appears to result in a high risk of thrombosis (11).
对22例肾病综合征患儿的主要凝血和纤溶蛋白进行了研究。一些异常情况，如纤维蛋白原、凝血因子II、V、VII + X浓度升高以及抗凝血酶III浓度降低，可能会导致高凝状态。其他异常情况，如α2巨球蛋白浓度升高和纤溶酶原浓度经常降低，可能会导致血浆纤溶活性降低。α1抗胰蛋白酶水平降低的影响可能不太重要。已发现不同患者的α2抗纤溶酶水平变化不定。实际上，似乎大多数血浆白蛋白水平低于15 - 17 g/l的儿童抗凝血酶III水平低于23 mg/dl（正常水平的70%），这似乎会导致血栓形成的高风险（11）。
