24-羟基和28-羟基中间体在黄粉虫β-谷甾醇代谢中的作用。
Role of 24- and 28-hydroxylated intermediates in the metabolism of beta-sitosterol in the insect Tenebrio molitor.
作者信息
Nicotra F, Ronchetti F, Russo G, Toma L
出版信息
Biochem J. 1979 Dec 1;183(3):495-9. doi: 10.1042/bj1830495.
Abstract
- [28-3H]Stigmast-5-ene-3 beta, 28-diol and [23,23,25-3H]stigmast-5-ene-3 beta, 24-diol were synthesized. 2. Each of the samples was mixed with beta-[4-14C]sitosterol and administered to Tenebrio molitor larvae. 3. The former compound is not utilized by the insect; the latter, although metabolized to 24(28)-ethylidene sterols and cholesterol, is not a beta-sitosterol metabolite. 4. The above results are discussed in relation to the mechanism of formation of the 24(28)-double bond in beta-sitosterol metabolism in T. molitor.
摘要
- 合成了[28 - ³H]豆甾-5-烯-3β,28-二醇和[23,23,25 - ³H]豆甾-5-烯-3β,24-二醇。2. 每个样品都与β-[4 - ¹⁴C]谷甾醇混合，并施用于黄粉虫幼虫。3. 前一种化合物未被昆虫利用；后一种化合物虽然代谢为24(28)-亚乙基甾醇和胆固醇，但不是β-谷甾醇的代谢产物。4. 结合黄粉虫β-谷甾醇代谢中24(28)-双键形成的机制对上述结果进行了讨论。
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本文引用的文献
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Identification of fucosterol as a metabllite and probable intermediate in conversion of beta-sitosterol to cholesterol in the tobacco hornworm.鉴定岩藻甾醇作为烟草天蛾中β-谷甾醇转化为胆固醇的一种代谢物及可能的中间体。
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