盐敏感性高血压的 Dahl S 大鼠体内的一种循环体液升压因子。

A circulating humoral pressor agent in Dahl S rats with salt hypertension.

Tobian L, Pumper M, Johnson S, Iwai J

Clin Sci (Lond). 1979 Dec;57 Suppl 5:345s-347s. doi: 10.1042/cs057345s.

Abstract

In Dahl S rats becoming hypertensive while on a diet of high NaCl content there appears to be a blood-borne humoral agent which produces vasoconstriction in a bioassay using the isolated hindquarters of rats. 2. This vasoconstrictor effect strongly suggests the presence of a humoral pressor agent or the lack of a vasodilator agent in the blood of hypertensive S rats. 3. The vasoconstrictor effect is not due to high renin concentrations. 4. This humoral vasoconstrictor action could partly account for the high vascular resistance in the hypertensive S rat.

摘要

在食用高氯化钠含量饮食时血压升高的 Dahl S 大鼠中，似乎存在一种通过使用大鼠离体后肢进行生物测定而产生血管收缩作用的血源性激素介质。2. 这种血管收缩作用强烈提示高血压 S 大鼠血液中存在一种体液升压剂或缺乏血管舒张剂。3. 这种血管收缩作用并非由于肾素浓度过高所致。4. 这种体液性血管收缩作用可能部分解释了高血压 S 大鼠的高血管阻力。