香豆素及某些香豆素衍生物对鸡和大鼠离体肠段糖类主动转运和被动扩散的影响。
Effect of coumarin and some coumarin derivatives on active transport and passive diffusion of sugars by chicken and rat intestine, in vitro.
作者信息
Larralde J, Ruano M J, Bolufer J, Jordana R
出版信息
Arch Int Physiol Biochim. 1975 May;83(2):271-9. doi: 10.3109/13813457509081871.
The effect of coumarin, 4-hydroxycoumarin, coumarin-3-carboxylic acid and acenocoumarol on the active transport of D-galactose and the passive diffusion of arabinose by intestinal sacs was studied. All these substances, when added to the mucosal medium of incubation at concentrations from 10(-4) to 10(-3) M, inhibit the active transport of D-galactose and increase the diffusion of arabinose. Oxygen uptake by the intestinal tissue is only inhibited by coumarin-3-carboxylic acid. The results suggest that the effects obtained are probably due to an alteration in intestinal permeability, to inhibition of cell metabolism and to molecular size.
研究了香豆素、4-羟基香豆素、香豆素-3-羧酸和醋硝香豆素对肠囊主动转运D-半乳糖及阿拉伯糖被动扩散的影响。当将所有这些物质以10⁻⁴至10⁻³M的浓度添加到孵育的黏膜介质中时，它们均会抑制D-半乳糖的主动转运并增加阿拉伯糖的扩散。肠组织对氧气的摄取仅受到香豆素-3-羧酸的抑制。结果表明，所获得的这些效应可能是由于肠道通透性改变、细胞代谢受到抑制以及分子大小所致。
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