Yamamoto S
Environ Health Perspect. 1979 Oct;32:19-20. doi: 10.1289/ehp.793219.
The role of mathematics in cancer research is not confined to epidemiology (population level). The expected contribution of it in various levels is exemplified stepwise. At the individual level, prediction of life expectancy of a cancer case or psychological analysis of life-threatened patient; at the tissue level, stochastic estimation of future metastases; at the cellular level, model contruction for abnormal metabolic processes in malignant cell; at the molecular level, elucidation of carcinogenetic mechanism from a thermodynamic standpoint of view.
数学在癌症研究中的作用并不局限于流行病学（群体层面）。它在各个层面的预期贡献将逐步得到例证。在个体层面，预测癌症患者的预期寿命或对面临生命威胁的患者进行心理分析；在组织层面，对未来转移进行随机估计；在细胞层面，构建恶性细胞异常代谢过程的模型；在分子层面，从热力学角度阐明致癌机制。
