甲状腺素生物合成的模型反应。由4-羟基-3-碘苯丙酮酸、3,5-二碘酪氨酸和氧气非酶促形成3,5,3'-三碘甲状腺原氨酸。 - Suppr | 超能文献

Model reactions for the biosynthesis of thyroxine. Nonenzymic formation of 3,5,3'-triiodothyronine from 4-hydroxy-3-iodophenylpyruvic acid, 3,5-diiodotyrosine, and oxygen.

作者信息

Cahnmann H J, Funakoshi K

出版信息

Biochemistry. 1970 Jan 6;9(1):90-8. doi: 10.1021/bi00803a012.

DOI:10.1021/bi00803a012

Abstract

摘要

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Model reactions for the biosynthesis of thyroxine. Nonenzymic formation of 3,5,3'-triiodothyronine from 4-hydroxy-3-iodophenylpyruvic acid, 3,5-diiodotyrosine, and oxygen.甲状腺素生物合成的模型反应。由4-羟基-3-碘苯丙酮酸、3,5-二碘酪氨酸和氧气非酶促形成3,5,3'-三碘甲状腺原氨酸。

Biochemistry. 1970 Jan 6;9(1):90-8. doi: 10.1021/bi00803a012.

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Model reactions for the biosynthesis of thyroxine. XII. The nature of a thyroxine precursor formed in the synthesis of thyroxine from diiodotyrosine and its keto acid analog.

Biochemistry. 1968 Jan;7(1):388-97. doi: 10.1021/bi00841a049.

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MODEL REACTIONS FOR THE BIOSYNTHESIS OF THYROXINE. X. NON-ENZYMIC FORMATION OF THYROXINE AND 3,3',5'-TRIIODOTHYRONINE RESIDUES IN THYROGLOBULIN.甲状腺素生物合成的模型反应。X. 甲状腺球蛋白中甲状腺素和3,3',5'-三碘甲状腺原氨酸残基的非酶促形成。

Biochim Biophys Acta. 1965 Mar 8;97:523-51. doi: 10.1016/0304-4165(65)90165-0.

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Model reactions for the biosynthesis of thyroxine. XI. The nature of a free radical formed in the autoxidation of 4-hydroxy-3,5-diiodophenylpyruvic acid.

J Org Chem. 1968 Jan;33(1):157-62. doi: 10.1021/jo01265a029.

5

[On the synthesis of thyroxin by condensation of 3,5-diiodotyrosine and 4-hydroxy-3,5-diiodophenylpyruvic acid].[关于通过3,5-二碘酪氨酸与4-羟基-3,5-二碘苯丙酮酸缩合合成甲状腺素]

C R Hebd Seances Acad Sci. 1963 Apr 29;256:3898-900.

6

[Inhibition of thyroxine synthesis from diiodotyrosine and diiodohydroxy-phenylpyruvic acid by agents blocking the free radicals].[通过阻断自由基的试剂抑制由二碘酪氨酸和二碘羟基苯丙酮酸合成甲状腺素]

C R Seances Soc Biol Fil. 1966;160(7):1403-8.

7

Enzymic pathway for thyroxine synthesis through p-hydroxy-3,5-diiodophenylpyruvic acid.通过对羟基-3,5-二碘苯丙酮酸合成甲状腺素的酶促途径。

Endocrinology. 1969 Sep;85(3):542-51. doi: 10.1210/endo-85-3-542.

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TSH stimulation of diiodotyrosine--aminotransaminase in the rat thyroid.

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The formation of thyroxine from diiodotyrosine in the presence of horseradish peroxidase and hydrogen peroxide.在辣根过氧化物酶和过氧化氢存在的情况下，由二碘酪氨酸形成甲状腺素。

Biochim Biophys Acta. 1965 Oct 18;107(3):434-40. doi: 10.1016/0304-4165(65)90187-x.

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EFFECT OF TEMPERATURE, PH AND TIME OF INCUBATION ON THE RADIOIODINE METABOLISM OF WHOLE RAT THYROID LOBES INCUBATED IN VITRO.温度、pH值及孵育时间对体外孵育的大鼠全甲状腺叶放射性碘代谢的影响

Endocrinology. 1964 Nov;75:698-705. doi: 10.1210/endo-75-5-698.

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