Kupiecki F P, Schneider D I
J Lipid Res. 1970 Jan;11(1):38-41.
5-Methylpyrazole-3-carboxylic acid (U-19425) and nicotinic acid, which apparently inhibit lipolysis in vivo as indicated by low plasma FFA and glycerol concentrations, stimulate lipolysis in vitro in adipose tissue removed from fasted rats 30-90 min after treatment. This stimulation is not the result of low initial levels of FFA in adipose tissue. An increased rate of lipolysis is not induced in vitro by preincubating tissue of untreated rats with U-19425. The increase can be blocked in incubated adipose tissue of U-19425-treated animals if U-19425 is added to the incubation medium. The beta-adrenergic blocking agent propranolol, at a concentration which inhibits epinephrine-stimulated lipolysis, does not affect the increase produced by administration of U-19425.
5-甲基吡唑-3-羧酸（U-19425）和烟酸，从低血浆游离脂肪酸（FFA）和甘油浓度表明它们在体内明显抑制脂肪分解，但在处理后30 - 90分钟从禁食大鼠取出的脂肪组织中，它们在体外刺激脂肪分解。这种刺激不是脂肪组织中FFA初始水平低的结果。用U-19425预孵育未处理大鼠的组织在体外不会诱导脂肪分解速率增加。如果将U-19425添加到孵育培养基中，在U-19425处理动物的孵育脂肪组织中增加的脂肪分解可被阻断。β-肾上腺素能阻断剂普萘洛尔，在抑制肾上腺素刺激的脂肪分解的浓度下，不影响U-19425给药产生的脂肪分解增加。
