Serota F T, Baserga R
Science. 1970 Mar 6;167(3923):1379-80. doi: 10.1126/science.167.3923.1379.
Polyinosinic acid * polycytidylic acid (poly I * poly C) inhibits isoproterenol-stimulated DNA synthesis in salivary glands of mice. A single intraperitoneal injection of 250 micrograms of poly I * poly C inhibits the stimulation of DNA synthesis when given 10 minutes before isoproterenol or at any time during the 20-hour lag period between the injection of isoproterenol and the subsequent DNA synthesis. The inhibition caused by poly I * poly C is not due to a generalized toxic action but seems to be exerted through a relatively selective mechanism. Polyuridylic acid and diethylaminoethyl dextran are less effective in inhibiting isoproterenol-stimulated DNA synthesis.
聚肌苷酸 * 聚胞苷酸（poly I * poly C）可抑制异丙肾上腺素刺激的小鼠唾液腺DNA合成。腹腔注射250微克poly I * poly C，若在异丙肾上腺素给药前10分钟或在注射异丙肾上腺素与随后的DNA合成之间20小时的延迟期内的任何时间给药，均可抑制DNA合成的刺激。poly I * poly C引起的抑制并非由于普遍的毒性作用，而是似乎通过相对选择性的机制发挥作用。聚尿苷酸和二乙氨基乙基葡聚糖在抑制异丙肾上腺素刺激的DNA合成方面效果较差。
