测定服用复方磺胺多辛的人体受试者中氨苯砜、单乙酰氨苯砜和乙胺嘧啶的血浆浓度。
Determination of plasma concentrations of dapsone, monoacetyl dapsone and pyrimethamine in human subjects dosed with maloprim.
作者信息
Jones C R, Ovenell S M
出版信息
J Chromatogr. 1979 Jun 11;163(2):179-85. doi: 10.1016/s0378-4347(00)81461-9.
PMID:541369
Abstract
A high-performance liquid chromatographic method was developed to enable dapsone, monoacetyl dapsone and pyrimethamine to be measured simultaneously in plasma samples from volunteers in England and Malaysia who had been dosed with Maloprim. Mean half-lives of 25 and 80 h were calculated for dapsone and pyrimethamine, respectively, but there was wide individual variation. All subjects were found to be classifiable as "slow acetylators".
摘要
建立了一种高效液相色谱法，用于同时测定英格兰和马来西亚服用了乙胺嘧啶-氨苯砜复方制剂（Maloprim）的志愿者血浆样本中的氨苯砜、单乙酰氨苯砜和乙胺嘧啶。计算得出氨苯砜和乙胺嘧啶的平均半衰期分别为25小时和80小时，但个体差异较大。所有受试者均被归类为“慢乙酰化者”。
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