Tamagna E I, Levine G A, Hershman J M
J Nucl Med. 1979 May;20(5):387-91.
Fourteen hyperthyroid patients (11 men, three women), ages 28-66, were followed with serial measurements of serum thyroid hormone levels for 1 mo after therapy with I-131. Twelve patients had diffuse toxic goiters (25--70 g in size); two patients had multinodular glands (40--100 g). The patients were taking no antithyroid medications; ten patients were treated with propranolol. All patients received the equivalent of 5000 rad, except the two with multinodular glands, who received larger doses. There was no consistent pattern of serum T4 and T3 levels after the I-131 therapy. For the entire group, there was no significant increase of the mean serum hormone concentration. One group (three patients) had a mean T4 increase of 28% and a T3 increase of 91% above baseline at Days 10--11. Seven patients had minimal increases of hormone levels at Days 2--3, and a third group (four patients) had no increase of thyroid hormones after I-131 therapy. The patients with no rise in hormone concentrations had smaller goiters than the other groups. There was no correlation of the dose of radioactive iodine, or of the initial hormone concentration, with the rises or declines of T4 and T3 levels after I-131 therapy. Radioiodine therapy caused no significant increase of serum T4 and T3 concentrations in the majority of patients.
14例甲状腺功能亢进患者（11例男性，3例女性），年龄28 - 66岁，在接受131碘治疗后连续1个月监测血清甲状腺激素水平。12例患者患有弥漫性毒性甲状腺肿（大小为25 - 70克）；2例患者患有多结节性腺体（40 - 100克）。患者未服用抗甲状腺药物；10例患者接受了普萘洛尔治疗。除2例多结节性腺体患者接受较大剂量外，所有患者均接受了相当于5000拉德的剂量。131碘治疗后血清T4和T3水平没有一致的模式。对于整个组，平均血清激素浓度没有显著增加。一组（3例患者）在第10 - 11天平均T4增加28%，T3增加91%，高于基线水平。7例患者在第2 - 3天激素水平仅有轻微增加，第三组（4例患者）在131碘治疗后甲状腺激素没有增加。激素浓度未升高的患者甲状腺肿比其他组小。放射性碘剂量或初始激素浓度与131碘治疗后T4和T3水平的升高或降低没有相关性。放射性碘治疗在大多数患者中未导致血清T4和T3浓度显著增加。
