Deal C W, Warden J C, Monk I
Thorax. 1970 Jan;25(1):105-9. doi: 10.1136/thx.25.1.105.
The changes in pulmonary compliance have been studied under conditions of total body hypothermia. Five groups of sheep were used; two groups were controls—one for the effects of anaesthesia and the other for normothermic biventricular bypass. The third group was cooled using a femoro-femoral arterio-venous shunt to 20°-23° C. The fourth group was cooled to 15° C. and rewarmed using the Drew technique. The excised lungs of the remaining sheep were studied at 37° and 15° C. (fifth group). The controls showed little change in compliance. The cooled animals showed a decrease in compliance. In the group subjected to hypothermia by the Drew technique, the rewarming phase initially brought a return towards normal compliance. As the temperature rose to 24°-30° C. the improvement in compliance ceased and thereafter compliance decreased for two hours after rewarming. Histologically the lungs were normal. There was no compliance change caused by cooling the excised lungs.
已经在全身低温的条件下研究了肺顺应性的变化。使用了五组绵羊；两组为对照组——一组用于研究麻醉的影响，另一组用于研究常温双心室旁路的影响。第三组使用股-股动静脉分流术将体温降至20°-23°C。第四组冷却至15°C，并采用德鲁技术复温。对其余绵羊切除的肺在37°C和15°C下进行研究（第五组）。对照组的顺应性变化很小。冷却的动物顺应性降低。在采用德鲁技术进行低温处理的组中，复温阶段最初使顺应性恢复到接近正常水平。当温度升至24°-30°C时，顺应性的改善停止，此后复温后两小时顺应性下降。组织学检查显示肺正常。切除的肺冷却未引起顺应性变化。
