Roberton N R
Arch Dis Child. 1970 Apr;45(240):206-14. doi: 10.1136/adc.45.240.206.
The use of THAM in the treatment of neonatal acidaemia is surveyed over a 3-year period. Of 100 babies to whom the drug was given while they were breathing spontaneously, 17% had respiratory depression during, or within two minutes of injection. If only potentially viable babies are considered, the incidence of respiratory depression increases to 20% and the incidence in babies with respiratory distress is 17%. No single group of babies was particularly susceptible to this action of THAM, except those who had had a previous spontaneous apnoeic attack. No babies became apnoeic after the injection of sodium bicarbonate. It appears that in the 'good prognosis' group according to the hyperoxia test those babies who require correction of their H have a higher death rate than those who do not. There was no statistically significant increase in the death rate of babies who deteriorated after THAM, but several of these babies only survived after treatment with artificial ventilation. There was an increased incidence of intraventricular haemorrhage in those babies who received 7% THAM rather than 3·60% THAM, but this may be due to other factors in their illness.
在三年期间对氨丁三醇（THAM）治疗新生儿酸血症的使用情况进行了调查。在100名自主呼吸时接受该药物治疗的婴儿中，17%在注射期间或注射后两分钟内出现呼吸抑制。如果仅考虑可能存活的婴儿，呼吸抑制的发生率增至20%，而有呼吸窘迫的婴儿中这一发生率为17%。除了之前有过自主呼吸暂停发作的婴儿外，没有哪一组婴儿对THAM的这种作用特别敏感。注射碳酸氢钠后没有婴儿出现呼吸暂停。根据高氧试验，在“预后良好”组中，那些需要纠正氢离子浓度（H）的婴儿的死亡率高于不需要纠正的婴儿。接受THAM治疗后病情恶化的婴儿死亡率没有统计学上的显著增加，但其中几名婴儿仅在接受人工通气治疗后存活。接受7%THAM而非3.60%THAM治疗的婴儿脑室内出血发生率增加，但这可能归因于其病情中的其他因素。
