ω-氨基酸及相关化合物对小鼠葡萄球菌感染的影响：一种预防性-治疗性联合程序
Effects of omega-amino acids and related compounds on staphylococcal infections in mice: a combined prophylactic-therapeutic procedure.
作者信息
Tsuchiya Y, Tanaka K, Cook E S, Nutini L G
出版信息
Appl Microbiol. 1970 May;19(5):813-7. doi: 10.1128/am.19.5.813-817.1970.
By a short-term combined prophylactic-therapeutic procedure, the following compounds were found to be active against staphylococcal infections in Swiss mice: gamma-aminobutyric acid, gamma-amino-beta-hydroxybutyric acid (GABOB), delta-amino-valeric acid (DAVA), epsilon-aminocaproic acid (EACA), trans-4-aminomethylcyclohexanecarboxylic acid (trans-AMCHA), taurine, and cysteic acid. Many of these compounds had displayed limited or no activity by a previously used prophylactic procedure. Although DAVA and GABOB were the most potent of the straight-chain omega-amino acids, trans-AMCHA displayed the greatest antistaphylococcic activity of the omega-amino acids thus far investigated. Homocarnosine (gamma-aminobutyrl histidine, which also was active by the prophylactic procedure) equalled trans-AMCHA in activity. Taurine was similar in potency to DAVA, and the activity of cysteic acid approximated that of EACA.
通过短期联合预防 - 治疗程序，发现以下化合物对瑞士小鼠的葡萄球菌感染具有活性：γ-氨基丁酸、γ-氨基 -β-羟基丁酸（GABOB）、δ-氨基戊酸（DAVA）、ε-氨基己酸（EACA）、反式 -4-氨甲基环己烷羧酸（反式 -AMCHA）、牛磺酸和半胱氨酸。这些化合物中的许多通过先前使用的预防程序显示出有限的活性或无活性。尽管DAVA和GABOB是直链ω-氨基酸中最有效的，但反式 -AMCHA在迄今为止研究的ω-氨基酸中显示出最大的抗葡萄球菌活性。高肌肽（γ-氨基丁酰组氨酸，通过预防程序也具有活性）在活性上与反式 -AMCHA相当。牛磺酸在效力上与DAVA相似，半胱氨酸的活性接近EACA。
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