人体中肌肽及其组成氨基酸的肠道吸收
Intestinal absorption of carnosine and its constituent amino acids in man.
作者信息
Asatoor A M, Bandoh J K, Lant A F, Milne M D, Navab F
出版信息
Gut. 1970 Mar;11(3):250-4. doi: 10.1136/gut.11.3.250.
Abstract
Serum concentrations of beta-alanine and l-histidine are compared in five normal adults after ingestion of the dipeptide carnosine (beta-alanyl-l-histidine) and after equivalent amounts of the constituent free amino acids. The results indicate that absorption is significantly more rapid after the ingestion of the amino acids than after the dipeptide. The use of the test in a case of Hartnup disease suggests that carnosine is taken up by intestinal cells as the dipeptide, but subsequent hydrolysis and delivery of the constituent amino acids to the portal blood is a slower process than transport of the free amino acids themselves.
摘要
在五名正常成年人摄入二肽肌肽（β-丙氨酰-L-组氨酸）以及等量的组成性游离氨基酸后，比较了他们血清中β-丙氨酸和L-组氨酸的浓度。结果表明，摄入氨基酸后吸收明显比摄入二肽后更快。在一名哈特纳普病患者中进行该测试表明，肌肽作为二肽被肠道细胞摄取，但随后组成性氨基酸的水解和向门静脉血的输送过程比游离氨基酸本身的转运过程更慢。
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本文引用的文献
1
Hyper-beta-alaninemia associated with beta-aminoaciduria and gamma-aminobutyricaciduria, somnolence and seizures.与β-氨基酸尿症、γ-氨基丁酸尿症、嗜睡和癫痫相关的高β-丙氨酸血症。
N Engl J Med. 1966 Mar 24;274(12):635-43. doi: 10.1056/NEJM196603242741201.
2
Active stereochemically selective absorption of amino-acids from rat small intestine.大鼠小肠对氨基酸的主动立体化学选择性吸收
J Physiol. 1951 Jun;114(1-2):7-8p.
3
Intracellular hydrolysis of dipeptides during intestinal absorption.肠道吸收过程中二肽的细胞内水解。
J Physiol. 1960 Jul;152(2):367-80. doi: 10.1113/jphysiol.1960.sp006493.
4
Cellular mechanisms in intestinal transfer of amino acids.氨基酸肠道转运中的细胞机制。
J Physiol. 1962 Dec;164(3):527-51. doi: 10.1113/jphysiol.1962.sp007035.
5
The metabolic disorder in Hartnup disease.哈丁普病中的代谢紊乱。
Q J Med. 1960 Jul;29:407-21.
6
The absorption of peptides.肽的吸收
Biochim Biophys Acta. 1959 Mar;32(1):69-73. doi: 10.1016/0006-3002(59)90553-0.
7
Carnosine and carnosinase in rat tissue.大鼠组织中的肌肽和肌肽酶
Nature. 1957 Jul 6;180(4575):39-40. doi: 10.1038/180039a0.
8
An ion exchange method of determining carnosine, anserine and their precursors in animal tissue.一种测定动物组织中肌肽、鹅肌肽及其前体的离子交换方法。
Nature. 1957 Jan 26;179(4552):209-10. doi: 10.1038/179209a0.
9
Action of proteolytic enzymes on some peptides and derivatives containing histidine.
J Biol Chem. 1956 Dec;223(2):935-47.
10
The excretion of amino acids by the human; a quantitative study with ion-exchange chromatography.人体氨基酸的排泄；离子交换色谱法定量研究
Biochem J. 1956 Mar;62(3):416-27. doi: 10.1042/bj0620416.
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