利福平诱导的免疫性血小板减少症。
Rifampicin-induced immune thrombocytopenia.
作者信息
Blajchman M A, Lowry R C, Pettit J E, Stradling P
出版信息
Br Med J. 1970 Jul 4;3(5713):24-6. doi: 10.1136/bmj.3.5713.24.
Abstract
A case is reported in which severe thrombocytopenia occurred during administration and readministration of rifampicin. The patient's erythrocytes gave a positive direct antiglobulin test due to complement on the red cell surface; in the serum, complement-fixing antibodies were detected which were directed against the drug.Immunological studies showed antibodies, of both IgG and IgM type, capable of fixing complement to both normal and the patient's platelets, but only in the presence of rifampicin. In addition the IgM type of antibody (but not the IgG) was capable of fixing complement to normal red cells; again only in the presence of the drug.
摘要
报告了一例在使用和再次使用利福平期间发生严重血小板减少症的病例。患者的红细胞因红细胞表面存在补体而直接抗球蛋白试验呈阳性；在血清中检测到针对该药物的补体结合抗体。免疫学研究表明，IgG和IgM类型的抗体均能够在利福平存在的情况下将补体固定于正常血小板和患者的血小板上。此外，IgM类型的抗体（而非IgG）能够在药物存在时将补体固定于正常红细胞上。
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