Salamon D J, Nusbacher J, Stroupe T, Wilson J H, Hanrahan J B
Transfusion. 1984 Sep-Oct;24(5):395-8. doi: 10.1046/j.1537-2995.1984.24585017827.x.
A patient was found to have a positive direct antiglobulin test and thrombocytopenia while on a moderate dose of intravenous penicillin. Serological evaluation of the patient's red cells demonstrated that the positive antiglobulin test was due to antipenicillin antibody. This antibody also was demonstrated in the patient's serum. The patient's platelets had increased quantities of IgG; an eluate from her platelets gave positive test results with platelets treated with penicillin but not normal platelets. Her serum also reacted only with penicillin-treated platelets. Multiple absorptions of her serum with red cells treated with penicillin reduced reactivity against both fresh red cells and platelets treated with penicillin. This patient demonstrated the coexistence of drug-induced immune phenomena directed against both red cells and platelets.
一名患者在接受中等剂量静脉注射青霉素治疗时，直接抗球蛋白试验呈阳性且出现血小板减少。对该患者红细胞的血清学评估表明，抗球蛋白试验阳性是由抗青霉素抗体所致。该抗体在患者血清中也得到证实。患者血小板的IgG含量增加；其血小板洗脱液与经青霉素处理的血小板反应呈阳性，但与正常血小板反应呈阴性。她的血清也仅与经青霉素处理的血小板发生反应。用经青霉素处理的红细胞对其血清进行多次吸收后，可降低其对新鲜红细胞和经青霉素处理的血小板的反应性。该患者表现出针对红细胞和血小板的药物诱导免疫现象并存。
