Lunn J N, Elwood P C
Br Med J. 1970 Jul 11;3(5714):71-3. doi: 10.1136/bmj.3.5714.71.
In 1,584 patients who had received an anaesthetic the association was examined between circulating haemoglobin level and the postoperative course (length of hospital stay, the occurrence of a complication, and death). In men a significant association (P<0.05) was found for each index, but in women this was present only for death.It is suggested that the hypothesis which best explains the associations, and is consistent with further analyses of the data, is that the preoperative haemoglobin level reflects the severity of the underlying condition which has necessitated surgery. A randomized clinical trial would test the alternative hypothesis that anaemia constitutes an additional risk in surgical procedures.
在1584例接受麻醉的患者中,研究了循环血红蛋白水平与术后病程(住院时间、并发症的发生及死亡)之间的关联。在男性患者中,每项指标均发现有显著关联(P<0.05),但在女性患者中,仅死亡这一指标存在关联。有人提出,最能解释这些关联且与数据的进一步分析一致的假说是,术前血红蛋白水平反映了需要进行手术的潜在疾病的严重程度。一项随机临床试验将检验另一种假说,即贫血在外科手术中构成额外风险。