滑膜渗出液中的血浆激肽。
Plasma kinins in synovial exudates.
作者信息
Eisen V
出版信息
Br J Exp Pathol. 1970 Jun;51(3):322-7.
Abstract
Kinin levels equivalent to 1-30 × 10 m bradykinin were found in 33 out of 82 exudates from rheumatoid joints. Only 2 of 27 fluids from joint effusions caused by osteoarthrosis or trauma, contained detectable levels of kinin (1-5 × 10 m bradykinin). The kinin concentrations showed little or no correlation with the white blood cell counts, protein concentrations and lactate dehydrogenase and acid phosphatase activities, in synovial fluids. Data on the pain felt in joints suggested that in higher concentrations kinins contribute to arthritic pain, but that other pain-producing factors are undoubtedly involved.
摘要
在82份类风湿性关节渗出液中，有33份检测到激肽水平相当于1 - 30×10⁻⁶M的缓激肽。在27份由骨关节炎或创伤引起的关节积液中，只有2份含有可检测水平的激肽（1 - 5×10⁻⁶M缓激肽）。滑膜液中的激肽浓度与白细胞计数、蛋白质浓度、乳酸脱氢酶和酸性磷酸酶活性几乎没有相关性。关于关节疼痛的数据表明，较高浓度的激肽会导致关节炎疼痛，但其他产生疼痛的因素无疑也参与其中。
相似文献
1
Plasma kinins in synovial exudates.滑膜渗出液中的血浆激肽。
Br J Exp Pathol. 1970 Jun;51(3):322-7.
2
[Correlation between single synovial fluid components in hydrarthrosis of various etiology].
Beitr Rheumatol. 1972;18:120-5.
3
Intracellular enzymes and kinin enzymes in synovial fluid in joint diseases. Origin and relation to disease category.关节疾病中滑液内的细胞内酶和激肽酶。来源及与疾病类别的关系。
Ann Rheum Dis. 1969 Sep;28(5):497-512. doi: 10.1136/ard.28.5.497.
4
[Cyclic nucleotides and enzymes of the synovial fluid in various rheumatic diseases].[各种风湿性疾病中滑液的环核苷酸与酶]
Rev Rhum Mal Osteoartic. 1980 Jul-Sep;47(7-9):461-4.
5
Temperature and biochemical studies of joint inflammation. A preliminary investigation.关节炎症的温度及生化研究。一项初步调查。
Ann Rheum Dis. 1970 Jul;29(4):386-92. doi: 10.1136/ard.29.4.386.
6
[New research on synovial enzymology].
Rev Rhum Mal Osteoartic. 1976 May;43(5):339-43.
7
Acid phosphatase activity in synovial fluid.
Nihon Geka Hokan. 1966 Nov 1;35(6):1010-9.
8
[Cytological and biochemical changes in the synovial fluid following varicocid administration].
Z Gesamte Inn Med. 1973 Nov 15;28(22):694-7.
9
Urate crystal induced inflammation in dog joints: sequence of synovial changes.尿酸盐结晶诱发犬关节炎症：滑膜变化的顺序
J Rheumatol. 1974 Mar;1(1):102-13.
10
[Cytochemical observations on rheumatoid synovial fluid].[类风湿性滑液的细胞化学观察]
Reumatismo. 1977 Jan-Mar;29(1):39-55.
引用本文的文献
1
Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis.膜受体和离子通道的变化作为骨关节炎的潜在生物标志物
Front Physiol. 2015 Dec 1;6:357. doi: 10.3389/fphys.2015.00357. eCollection 2015.
2
Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts.缓激肽介导的新型作用及人滑膜成纤维细胞中缓激肽 B2 受体拮抗作用的药理学特征。
Br J Pharmacol. 2009 Dec;158(8):1996-2004. doi: 10.1111/j.1476-5381.2009.00511.x.
3
Soluble recombinant neutral endopeptidase (CD10) as a potential antiinflammatory agent.可溶性重组中性内肽酶（CD10）作为一种潜在的抗炎剂。
Inflammation. 1998 Feb;22(1):107-21. doi: 10.1023/a:1022304025789.
4
Mechanisms of prostanoid synthesis in human synovial cells: cytokine-peptide synergism.
Inflammation. 1996 Oct;20(5):537-54. doi: 10.1007/BF01487045.
5
A tissue kallikrein in the synovial fluid of patients with rheumatoid arthritis.类风湿性关节炎患者滑液中的一种组织激肽释放酶。
Ann Rheum Dis. 1989 Feb;48(2):128-33. doi: 10.1136/ard.48.2.128.
6
Kallikreins and kinins: mediators in inflammatory joint disease?激肽释放酶与激肽：炎症性关节病的介质？
Int J Exp Pathol. 1990 Aug;71(4):587-601.
7
Cultured human synovial fibroblasts rapidly metabolize kinins and neuropeptides.培养的人滑膜成纤维细胞能快速代谢激肽和神经肽。
J Clin Invest. 1992 Sep;90(3):981-91. doi: 10.1172/JCI115975.
8
Regulation of bradykinin-induced cyclic amp response by quinacrine and prostaglandin E2 and F2 alpha in human synovial fibroblasts.喹吖因、前列腺素E2和F2α对人滑膜成纤维细胞中缓激肽诱导的环磷酸腺苷反应的调节作用
Inflammation. 1979 Jul;3(3):235-42. doi: 10.1007/BF00914180.
9
Human synovial fibroblasts: the relationships between cyclic AMP, bradykinin, and prostaglandins.人滑膜成纤维细胞：环磷酸腺苷、缓激肽与前列腺素之间的关系
Agents Actions. 1977 Jul;7(2):255-64. doi: 10.1007/BF01969984.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Bradykinin and cardiovascular system: estimation of half-life.
Am J Physiol. 1962 Aug;203:261-5. doi: 10.1152/ajplegacy.1962.203.2.261.
3
LARGE MOLECULAR SUBSTANCES AS MEDIATORS OF THE INFLAMMATORY REACTION.作为炎症反应介质的大分子物质
Ann N Y Acad Sci. 1964 Aug 27;116:855-65. doi: 10.1111/j.1749-6632.1964.tb52551.x.
4
Pain-producing substance in human inflammatory exudates and plasma.人类炎性渗出物和血浆中的致痛物质。
J Physiol. 1957 Feb 15;135(2):350-70. doi: 10.1113/jphysiol.1957.sp005715.
5
A delayed slow contracting effect of serum and plasma due to the release of a substance resembling kallidin and bradykinin.血清和血浆因释放出一种类似胰激肽和缓激肽的物质而产生延迟性慢收缩效应。
Br J Pharmacol Chemother. 1956 Jun;11(2):111-8. doi: 10.1111/j.1476-5381.1956.tb01038.x.
6
Lactic dehydrogenase activity in blood.血液中的乳酸脱氢酶活性。
Proc Soc Exp Biol Med. 1955 Oct;90(1):210-3. doi: 10.3181/00379727-90-21985.
7
Kininase in human polymorphonuclear leukocytes.人多形核白细胞中的激肽酶
Life Sci. 1966 Dec;5(24):2347-55. doi: 10.1016/0024-3205(66)90072-5.
8
The in vitro inactivation and formation of plasma kinins by spleen cathepsins.脾脏组织蛋白酶对血浆激肽的体外灭活及生成作用
Br J Pharmacol Chemother. 1966 May;27(1):230-8. doi: 10.1111/j.1476-5381.1966.tb01658.x.
9
Urates and kinin formation in synovial fluid.滑液中尿酸盐和激肽的形成。
Proc R Soc Med. 1966 Apr;59(4):302-7. doi: 10.1177/003591576605900403.
10
A radioimmunoassay for bradykinin in plasma and synovial fluid.血浆和滑液中缓激肽的放射免疫测定法。
J Lab Clin Med. 1969 Nov;74(5):816-27.
Zotero 插件