Egekeze J O, Oehme F W
Toxicology. 1979 Dec;15(1):43-53. doi: 10.1016/0300-483x(79)90018-0.
Male rats were used to study the inorganic (ionic) and organic fluoride concentrations in plasma, liver, kidneys and stomach content after oral doses of 0, 2.2, 3.5, 4.0, 5.0 and 7.0 mg sodium monofluoroacetate (SMFA, Compound 1080)/kg body weight. Tissue and plasma ionic fluoride concentrations were observed to be higher in all rats given SMFA as compared to rats in the control group. This observation suggests in vivo defluorination of SMFA. Homogenates of liver obtained from SMFA poisoned rats showed significant increases in ionic fluoride concentration during a 6-day storage period at +4 degrees C, with the total fluoride concentration (ionic and organic) remaining constant. The average percentages of distribution of SMFA (organic fluoride) in plasma, liver, and kidneys were 7.05, 5.07 and 1.68, respectively. Plasma and tissue SMFA concentrations were generally lower than the corresponding stomach fluid SMFA concentrations for all dosage groups. Lethal concentration of SMFA in the liquid stomach content was in the range 84.9--189 micrograms/ml, corresponding to total (ionic and organic) fluoride concentrations in the range of 16.1--36 micrograms/ml.
使用雄性大鼠研究口服剂量为0、2.2、3.5、4.0、5.0和7.0毫克一氟乙酸钠（SMFA，化合物1080）/千克体重后，血浆、肝脏、肾脏和胃内容物中的无机（离子）和有机氟浓度。与对照组大鼠相比，观察到所有给予SMFA的大鼠的组织和血浆离子氟浓度更高。这一观察结果表明SMFA在体内发生了脱氟作用。从SMFA中毒大鼠获得的肝脏匀浆在4℃下储存6天期间，离子氟浓度显著增加，而总氟浓度（离子和有机）保持不变。SMFA（有机氟）在血浆、肝脏和肾脏中的平均分布百分比分别为7.05、5.07和1.68。对于所有剂量组，血浆和组织中的SMFA浓度通常低于相应胃液中的SMFA浓度。胃液中SMFA的致死浓度范围为84.9 - 189微克/毫升，对应总（离子和有机）氟浓度范围为16.1 - 36微克/毫升。
