Silverberg D S, Ulan R A, Baltzan M A, Baltzan R B
Can Med Assoc J. 1970 Jul 18;103(2):129-33.
Six cases of edema, three due to the nephrotic syndrome, one to congestive heart failure and two to chronic renal failure, are reported in which furosemide was administered in oral doses higher than those usually prescribed (up to 720 mg. a day), in order to obtain a satisfactory diuresis. In one case of severe prerenal failure secondary to cardiogenic shock and in one case of acute tubular necrosis secondary to hypotension at the time of operation, intravenous doses up to 990 and 1400 mg. per day respectively were able to reverse the oliguria. In eight additional patients who were on chronic hemodialysis, furosemide was administered to the amount of 1000 mg. per day orally in divided doses for two weeks, and produced a moderate diuretic response.The use of high doses of furosemide in edema and renal failure resistant to the usual therapeutic measures appears to be safe and effective.
报告了6例水肿患者，其中3例因肾病综合征，1例因充血性心力衰竭，2例因慢性肾衰竭，为获得满意的利尿效果，给予口服呋塞米的剂量高于通常规定剂量（每日高达720毫克）。1例继发于心源性休克的严重肾前性衰竭患者和1例手术时继发于低血压的急性肾小管坏死患者，分别静脉注射每日高达990毫克和1400毫克的剂量能够逆转少尿。另外8例接受慢性血液透析的患者，以每日1000毫克的剂量分多次口服呋塞米，持续两周，产生了中度利尿反应。在对常规治疗措施耐药的水肿和肾衰竭中使用高剂量呋塞米似乎是安全有效的。
