López Uriarte A, Maldonado Martínez E
Bol Med Hosp Infant Mex. 1978 May-Jun;35(3):523-7.
A case is reported of a female preschool, age child with nephrotic syndrome, probably secondary to focal and segmentary hyalinosis with progressive decrease of the renal function. The patient was given increasing doses of furosemide to control the important retention of fluids she showed until a daily dose of 120 mg/kg. of body weight was reached. Adequate control of edema was managed and it was possible to decrease sodium restriction from the diet when urinary excretion of sodium increased. Such effect was useful for four months during which, the patient's diet turned more adequate and there was improvement of the nutritional state which was seriously impaired because of the restrictive diet given. However, control was lost because the patient died at home from bronchopneumonia. Thus, it is considered furosemide may be used in chronic renal failure at higher than usual doses in selected patients.
报告了一例患有肾病综合征的学龄前女童病例，可能继发于局灶节段性玻璃样变性，且肾功能逐渐下降。给予该患者逐渐增加剂量的呋塞米以控制其明显的液体潴留，直至达到每日120mg/kg体重的剂量。水肿得到了充分控制，并且当尿钠排泄增加时，可以减少饮食中的钠限制。这种效果持续了四个月，在此期间，患者的饮食变得更加合理，营养状况得到改善，此前由于严格的饮食限制，营养状况严重受损。然而，最终失去了控制，因为患者在家中死于支气管肺炎。因此，认为在某些选定的患者中，呋塞米可用于慢性肾衰竭，剂量高于通常使用的剂量。
