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[环磷酰胺在免疫性血细胞减少症治疗中的应用]

[Cyclophosphamide in the treatment of immune hemocytopenias].

作者信息

Sakalová A, Hrubisko M

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1975;102(5):559-64.

PMID:54306
Abstract

Personal experiences with the immunosuppressive therapy of immunohaemocytopenia by cyclophosphamide are represented. A significant therapeutic success in autoimmunohaemolytic anaemia could be registered in 22 patients treated from one to seven years. From a number of 11 patients 9 were in complete remission. In idiopathic thrombocytopenia, however, only 7 patients from a number of 10 were in a clinical remission, the number of thrombocytes remained unchanged. The control of the complement content and the component C'3 can be used well as an indicator for immunological defense when the activity of the process and the success of the therapy are to be evaluated.

摘要

本文介绍了环磷酰胺免疫抑制疗法治疗免疫性血细胞减少症的个人经验。在接受治疗1至7年的22例自身免疫性溶血性贫血患者中取得了显著的治疗成功。在11例患者中,9例完全缓解。然而,在特发性血小板减少症中,10例患者中只有7例临床缓解,血小板数量未变。在评估免疫过程的活性和治疗效果时,补体含量及C'3成分的检测可作为免疫防御的良好指标。

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