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Quinacrine: mechanisms of antimalarial action.

作者信息

Van Dyke K, Lantz C, Szustkiewicz C

出版信息

Science. 1970 Jul 31;169(3944):492-3.

PMID:5432269
Abstract

Two new interesting modes of action of quinacrine have been discovered. The first concerns a dose-related inhibition of uptake of [8-(3)H] adenosine into host cells of parasitized blood. Second, the drug inhibits the incorporation of tritiated adenosine triphosphate primarily into RNA but also into DNA of the erythrocyte-free malarial parasite Plasmodium berghei.

摘要

相似文献

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Quinacrine: mechanisms of antimalarial action.
Science. 1970 Jul 31;169(3944):492-3.
2
Quinacrine: mechanisms of antimalarial action.
Science. 1970 Jul 31;169(3944):492-3.
3
Studies concerning the mechanism of action of antimalarial drugs. II. Inhibition of the incorporation of adenosine-5'-monophosphate- 3 H into nucleic acids of erythrocyte-free malarial parasites.
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Studies concerning the mechanism of action of antimalarial drugs. Inhibition of the incorporation of adenosine-8-3H into nucleic acids of Plasmodium berghei.关于抗疟药物作用机制的研究。腺苷 -8-³H掺入伯氏疟原虫核酸的抑制作用。
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The influence of methylene blue on the pentose phosphate pathway in erythrocytes of monkeys infected with Plasmodium knowlesi.
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Plasmodium berghei: in vitro incorporation of purine derivatives into nucleic acids.
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Apparent new modes of antimalarial action detected by inhibited incorporation of adenosine-8-3H into nucleic acids of Plasmodium berghei.通过抑制腺苷-8-³H掺入伯氏疟原虫核酸检测到的明显抗疟作用新方式。
Mil Med. 1969 Sep;134(10):1000-6.
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Isolation and analysis of nucleotides from erythrocyte-free malarial parasites (Plasmodium berghei) and potential relevance to malaria chemotherapy.从无红细胞疟原虫（伯氏疟原虫）中分离和分析核苷酸及其与疟疾化疗的潜在相关性。
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A unique antinucleic acid approach to the mass screening of antimalarial drugs.一种用于大规模筛选抗疟药物的独特抗核酸方法。
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[Nucleic acid metabolism in experimental malaria. 1. Studies on the incorporation of thymidine, uridine, and adenosine in the malaria parasite (Plasmodium berghei and Plasmodium vinckei)].[实验性疟疾中的核酸代谢。1. 疟原虫（伯氏疟原虫和温氏疟原虫）中胸苷、尿苷和腺苷掺入的研究]
Z Tropenmed Parasitol. 1967 Dec;18(4):456-62.

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