Pongrácz F, Szente M
Acta Physiol Acad Sci Hung. 1979;53(3):327-36.
Some effects of the convulsant drug pentylenetetrazol (PTZ) on molluscan neurons were simulated. The calculations were based on the voltage clamp results of Connor and Stevens as well as Williamson and Crill. The normal repetitive state and the PTZ-controlled state were compared and threshold phenomena shown by prolonged depolarizations were studied by injection of hyperpolarizing currents into the first segment of the cable model, which is a widely used description of electrical spread in neuronal membranes. The potassium leakage (concentration per unit area) occurring simultaneously with the fluctuations of the ionic components was also evaluated. It is concluded that the PTZ-controlled state may alter the profile of the potassium leakage both quantitatively and dynamically. The hyperpolarizing and depolarizing current sequences may be functionally related to the intracellular epileptiform discharges.
模拟了惊厥药物戊四氮（PTZ）对软体动物神经元的一些作用。计算基于康纳和史蒂文斯以及威廉姆森和克里尔的电压钳实验结果。比较了正常重复状态和PTZ控制状态，并通过向电缆模型的第一段注入超极化电流来研究长时间去极化所显示的阈值现象，电缆模型是对神经元膜电传播的一种广泛使用的描述。还评估了与离子成分波动同时发生的钾离子泄漏（单位面积浓度）。得出的结论是，PTZ控制状态可能在数量和动态方面改变钾离子泄漏的情况。超极化和去极化电流序列可能在功能上与细胞内癫痫样放电相关。
