Neuropharmacological activity of new derivatives of 3,3-diethyl-2,4-pyridinedione. IV. 1-alkyl derivatives of 3,3-diethyl-2,4-pyridinedione.

Neuropharmacological screening of five 1-alkyl derivatives of 3,3-diethyl-2,4-pyridinedione was performed on male albino mice. The substances studied manifest very good analgesic effect in the test involving intraperitoneal injection of glacial acetic acid. 1-Alkyl derivatives have no hypnotic effect. They potentiate hexobarbital anaesthesia (with the exception of 1-/4'-/2''-hydroxyethyl/-piperazinylpropano/-3,3-diethyl-2,4-pyridinedione). 1-/2-morpholinoethyl/-3,3-diethyl-5-hydroxymethyl-2,4-pyridinedione and 1-/2'-morpholinoethyl/-3,3-diethyl-5-/3',4',5'-trimethoxybenzoyloxymethyl/-2,4-pyridinedione inhibit the amphetamine-stimulated motor activity. The newly-synthesized substances have no anticonvulsant action in corazol convulsions. 1-Alkyl derivatives are found to manifest a central depressive action, differing from that of diethylpyridinedione.