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自发性高血压大鼠肠系膜小动脉和小静脉的形态学与力学特性

Morphological and mechanical properties of small mesenteric arteries and veins in spontaneously hypertensive rats.

作者信息

Aalkjaer C, Mulvany M J

出版信息

Acta Physiol Scand. 1979 Dec;107(4):309-12. doi: 10.1111/j.1748-1716.1979.tb06480.x.

DOI:10.1111/j.1748-1716.1979.tb06480.x
PMID:543427
Abstract

Segments of small mesenteric arteries(approximately 150 micrometer lumen diameter) and of corresponding veins were taken from 5-month-old spontaneously hypertensive rats(SHR) AND FROM AGE MATCHED Wistar Kyoto (WKY) controls. The segments were mounted on a myograph which enabled their mechanical and morphological parameters to be investigated simultaneously. Compared with the WKY arteries the lumen diameter of the SHR arteries was smaller while the media thickness and active wall tension response were greater. On the other hand there were no differences between the corresponding veins from SHR and WKY animals although, compared with the arteries, the veins had a greater lumen diameter, a smaller media thickness and a smaller tension response. The findings suggest that the morphological and mechanical differences seen in arteries from SHR are not found on the venous side.

摘要

从小肠系膜动脉(管腔直径约150微米)和相应的静脉中取出片段,这些样本取自5个月大的自发性高血压大鼠(SHR)以及年龄匹配的Wistar Kyoto(WKY)对照大鼠。将这些片段安装在肌动描记器上,以便能够同时研究它们的力学和形态学参数。与WKY动脉相比,SHR动脉的管腔直径较小,而中膜厚度和活性壁张力反应更大。另一方面,SHR和WKY动物相应静脉之间没有差异,尽管与动脉相比,静脉的管腔直径更大,中膜厚度更小,张力反应更小。这些发现表明,在SHR动脉中观察到的形态学和力学差异在静脉方面并未出现。

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