Zlotnik I, Harris W J
Br J Exp Pathol. 1970 Feb;51(1):37-42.
Although Semliki Forest virus and louping ill belong to 2 distinct serological groups of arboviruses, the general pattern of cellular changes and their mode of morphogenesis is similar. Severe changes in the mitochondria of neurons, leading to the formation of inclusion bodies have been described in both infections. The possible origin of globular bodies and of the intracytoplasmic membrane convolutions from mitochondria has been suggested. In both infections virus maturation is preceded by the appearance of large accumulations of particles resembling ribosomes. Definite morphogenesis of nucleoids was traced to the cytoplasmic matrix in the close vicinity of vesicular membranes, while maturation of virions was regularly observed in the endoplasmic reticulum and occasionally within the intracytoplasmic inclusion bodies. In louping ill however, mature virus particles were seen within the vesicles of the distended and hypertrophied Golgi apparatus.
虽然Semliki森林病毒和跳跃病病毒属于虫媒病毒的两个不同血清学组，但细胞变化的总体模式及其形态发生方式是相似的。在这两种感染中均已描述了神经元线粒体的严重变化，导致包涵体的形成。有人提出球状小体和线粒体内质网膜卷曲的可能起源。在这两种感染中，病毒成熟之前都会出现大量类似核糖体的颗粒堆积。核仁的明确形态发生可追溯到泡状膜附近的细胞质基质，而病毒粒子的成熟则经常在内质网中观察到，偶尔也在胞质内包涵体中观察到。然而，在跳跃病中，在扩张和肥大的高尔基体的囊泡内可见成熟的病毒颗粒。
