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成人乳糜泻患者肠道黏膜的肽水解酶活性

Peptide hydrolase activity of human intestinal mucosa in adult coeliac disease.

作者信息

Douglas A P, Peters T J

出版信息

Gut. 1970 Jan;11(1):15-7. doi: 10.1136/gut.11.1.15.

DOI:10.1136/gut.11.1.15
PMID:5435263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1411365/
Abstract

The levels of two peptide hydrolases were studied in intestinal mucosa from normal subjects, patients with untreated coeliac disease, and treated patients. The mucosa from the untreated patients had significantly reduced activity against glycyl-glycine and leucylleucine. No such difference was found for the treated patients and it was concluded that the reduction in peptidase activity was secondary to the mucosal damage.

摘要

研究了正常受试者、未经治疗的乳糜泻患者和已治疗患者的肠黏膜中两种肽水解酶的水平。未经治疗患者的肠黏膜对甘氨酰甘氨酸和亮氨酰亮氨酸的活性显著降低。已治疗患者未发现此类差异,得出的结论是肽酶活性降低是黏膜损伤的继发结果。

相似文献

1
Peptide hydrolase activity of human intestinal mucosa in adult coeliac disease.成人乳糜泻患者肠道黏膜的肽水解酶活性
Gut. 1970 Jan;11(1):15-7. doi: 10.1136/gut.11.1.15.
2
[Experimental studies on leucine aminopeptidase and glycyl glycine dipeptidase activities in the intestinal mucosa following surgery of the upper gastrointestinal system by various methods].[不同方法对上消化道系统手术后肠黏膜亮氨酸氨肽酶和甘氨酰甘氨酸二肽酶活性的实验研究]
Igaku Kenkyu. 1971 Feb;41(2):79-100.
3
Intestinal glutaminyl-proline dipeptidase activity in children with treated coeliac disease.经治疗的乳糜泻患儿的肠道谷氨酰胺基脯氨酸二肽酶活性
Rev Eur Etud Clin Biol. 1972 Dec;17(10):993-7.
4
Dipeptidase deficiency and malabsorption of glycylglycine in disease states.疾病状态下二肽酶缺乏与甘氨酰甘氨酸吸收不良
Gut. 1971 Apr;12(4):276-83. doi: 10.1136/gut.12.4.276.
5
Carnosinase activity of human gastrointestinal mucosa.人胃肠道黏膜的肌肽酶活性。
Gut. 1975 Aug;16(8):585-9. doi: 10.1136/gut.16.8.585.
6
Multiple forms of dipeptidases in normal human intestinal mucosa and in mucosa from children with coeliac disease.
Clin Chim Acta. 1969 Dec;26(3):555-8. doi: 10.1016/0009-8981(69)90087-4.
7
Disaccharidase activity and jejunal morphology in coeliac disease.乳糜泻中的双糖酶活性和空肠形态
Q J Med. 1972 Oct;41(164):457-76.
8
Intestinal dipeptidases and disaccharidases in children with malabsorption.吸收不良儿童的肠道二肽酶和双糖酶
Acta Paediatr Scand. 1970 Nov;59(6):621-30. doi: 10.1111/j.1651-2227.1970.tb17696.x.
9
Intestinal dipeptidases and disaccharidases in celiac disease in adults.成人乳糜泻中的肠道二肽酶和双糖酶
Gastroenterology. 1970 Oct;59(4):575-82.
10
Jejunal mucosal enzymes in untreated and treated coeliac disease.未经治疗和已治疗的乳糜泻患者空肠黏膜酶
Scand J Gastroenterol. 1983 Mar;18(2):251-6. doi: 10.3109/00365528309181591.

引用本文的文献

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Non-Host Factors Influencing Onset and Severity of Celiac Disease.非宿主因素对乳糜泻发病和严重程度的影响。
Gastroenterology. 2024 Jun;167(1):34-50. doi: 10.1053/j.gastro.2024.01.030. Epub 2024 Jan 28.
2
The emerging roles of bacterial proteases in intestinal diseases.细菌蛋白酶在肠道疾病中的新兴作用。
Gut Microbes. 2023 Jan-Dec;15(1):2181922. doi: 10.1080/19490976.2023.2181922.
3
Intestinal peptide transport and hydrolysis in health and disease.健康与疾病状态下的肠道肽转运与水解
Ir J Med Sci. 1979 Dec;148(1):123-34. doi: 10.1007/BF02938065.
4
Coeliac disease: A review of the causative agents and their possible mechanisms of action.乳糜泻:病因及其可能作用机制的综述。
Amino Acids. 1996 Mar;10(1):1-19. doi: 10.1007/BF00806090.
5
Dipeptidase deficiency and malabsorption of glycylglycine in disease states.疾病状态下二肽酶缺乏与甘氨酰甘氨酸吸收不良
Gut. 1971 Apr;12(4):276-83. doi: 10.1136/gut.12.4.276.
6
Coeliac disease. Some still controversial aspects.乳糜泻。一些仍存在争议的方面。
Arch Dis Child. 1972 Apr;47(252):292-8. doi: 10.1136/adc.47.252.292.
7
Intestinal peptidases.肠肽酶
Gut. 1970 Aug;11(8):720-5. doi: 10.1136/gut.11.8.720.
8
The enterocyte in coeliac disease.乳糜泻中的肠上皮细胞。
Br Med J. 1970 Oct 3;4(5726):14-7. doi: 10.1136/bmj.4.5726.14.
9
Amino acid and peptide absorption in patients with coeliac disease and dermatitis herpetiformis.乳糜泻和疱疹样皮炎患者的氨基酸和肽吸收情况
Gut. 1974 Jan;15(1):1-8. doi: 10.1136/gut.15.1.1.
10
Celiac disease--an inborn error of metabolism.乳糜泻——一种先天性代谢紊乱疾病。
Am J Dig Dis. 1973 Sep;18(9):797-800.

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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A CONTINUOUS, AUTOMATIC METHOD FOR THE STUDY OF RATE OF HYDROLYSIS OF PEPTIDES AND AMIDES.一种用于研究肽和酰胺水解速率的连续自动方法。
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[NONTROPICAL SPRUE: ETIOLOGY AND PATHOGENESIS].[非热带性口炎性腹泻:病因与发病机制]
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Gluten-induced enteropathy: the effect of partially digested gluten.麸质诱导的肠病:部分消化的麸质的作用
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On the growth defect in coelic disease.关于乳糜泻中的生长缺陷。
Proc R Soc Med. 1956 Dec;49(12):1009-13. doi: 10.1177/003591575604901210.
9
Intestinal dipeptidases. Dipeptidase activities in small intestinal biopsy specimens from a clinical material.肠二肽酶。临床材料中小肠活检标本中的二肽酶活性。
Scand J Gastroenterol. 1968;3(2):177-82. doi: 10.3109/00365526809180119.
10
Studies of jejunal mucosal digestion of peptic-tryptic digests of wheat protein in coeliac disease.乳糜泻患者中小肠黏膜对小麦蛋白胃蛋白酶-胰蛋白酶消化产物的消化研究。
Gut. 1966 Aug;7(4):368-71. doi: 10.1136/gut.7.4.368.