1,3-Bis(p-chlorobenzylideneamino)guanidine hydrochloride (robenzidene): new poultry anticoccidial agent.

At 66 parts per million in the feed, robenzidene is highly effective in preventing chicken coccidiosis caused by any one of eight Eimeria species. Three times this dose is safe for broiler chickens. In dogs and rats, the toxicity was relatively low over a period of 90 days. In laboratory trials, the drug completely prevents oocyst production by seven species and greatly reduces oocyst production by Eimeria maxima.