Pickrell K, Villarreal-Rios A, Neale H
Ann Plast Surg. 1979 Aug;3(2):172-6. doi: 10.1097/00000637-197908000-00015.
A patient with multiple keratoacanthomas association with a well-differentiated squamous cell carcinoma is presented. Incomplete excision of a keratoacanthoma deprives the pathologist of his main criteria in differentiating this lesion from a squamous cell carcinoma. Wide excision appears to be the treatment of choice. Multiple keratoacanthomas can be associated with squamous cell carcinomas, which initially look identical. Persistence with conservative treatment in a growing lesion can fail to deal with an invasive squamous cell carcinoma which will require disfiguring or mutilating operations to cure. Squamous cell carcinoma does develop in keratoacanthomas, but metastases are rare.
本文报告了一例患有多发性角化棘皮瘤并伴有高分化鳞状细胞癌的患者。角化棘皮瘤切除不完全会使病理学家失去区分该病变与鳞状细胞癌的主要标准。广泛切除似乎是首选的治疗方法。多发性角化棘皮瘤可能与鳞状细胞癌相关，最初两者看起来相同。对于不断生长的病变持续采用保守治疗可能无法应对侵袭性鳞状细胞癌，而后者需要进行毁容性或致残性手术才能治愈。鳞状细胞癌确实会在角化棘皮瘤中发生，但转移很少见。
