单线态氧与核酸成分之间的反应。光动力过程中反应的重要性。
Reactions between singlet oxygen and the constituents of nucleic acids. Importance of reactions in photodynamic processes.
作者信息
Hallett F R, Hallett B P, Snipes W
出版信息
Biophys J. 1970 Apr;10(4):305-15. doi: 10.1016/S0006-3495(70)86303-2.
Abstract
Bases, nucleosides, nucleotides, and polynucleotides were exposed to chemically generated singlet oxygen to determine whether the species oxidized paralleled those oxidized in photodynamic reactions. In neutral or basic aqueous solution guanine, guanosine, deoxyguanosine, guanylic acid, deoxyguanylic acid, thymine, and uracil reacted with singlet oxygen. Since these compounds are oxidized in photodynamic processes, this study provides further evidence that singlet oxygen is the active intermediate in the photodynamic oxidation of nucleic acid constituents. Dienophilic attack by singlet oxygen is considered to be a plausible mechanism in these reactions.
摘要
将碱基、核苷、核苷酸和多核苷酸暴露于化学产生的单线态氧中，以确定被氧化的物质是否与光动力反应中被氧化的物质相似。在中性或碱性水溶液中，鸟嘌呤、鸟苷、脱氧鸟苷、鸟苷酸、脱氧鸟苷酸、胸腺嘧啶和尿嘧啶与单线态氧发生反应。由于这些化合物在光动力过程中被氧化，本研究进一步证明单线态氧是核酸成分光动力氧化的活性中间体。单线态氧的亲双烯体攻击被认为是这些反应中一种合理的机制。
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