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石膏样小孢子菌对尼古丁的N-去甲基化作用及对尼古丁-1'-N-氧化物的还原作用。

N-demethylation of nicotine and reduction of nicotine-1'-N-oxide by Microsporum gypseum.

作者信息

Sindelar R D, Rosazza J P, Barfknecht C F

出版信息

Appl Environ Microbiol. 1979 Nov;38(5):836-9. doi: 10.1128/aem.38.5.836-839.1979.

DOI:10.1128/aem.38.5.836-839.1979
PMID:543700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC243596/
Abstract

Several microorganisms were examined for their abilities to convert S-nicotine into nornicotine. Five microorganisms including Microsporum gypseum (ATCC 11395) produced nornicotine and three unknown metabolites. M. gypseum efficiently reduced nicotine-1'-N-oxide to nicotine, but no nornicotine was obtained when the N-oxide was used as substrate.

摘要

研究了几种微生物将S-尼古丁转化为去甲烟碱的能力。包括石膏样小孢子菌（ATCC 11395）在内的五种微生物产生了去甲烟碱和三种未知代谢物。石膏样小孢子菌能有效地将烟碱-1'-N-氧化物还原为烟碱，但当以N-氧化物为底物时，未得到去甲烟碱。

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