Fontaine J, Reuse J
Arch Int Pharmacodyn Ther. 1979 Nov;242(1):149-58.
The effects of metoclopramide (Mcp), a benzamide derivative, have been quantitatively analyzed on the responses of the isolated guinea-pig ileum to transmural stimulation. Mcp (0.03 microgram ml-1 upwards) increased these responses but this effect which was calcium-dependent was not concentration-dependent (up to 30 micrograms ml-1). Mcp antagonized the inhibitor effects of noradrenaline, dopamine, procaïne, adenosine triphosphate, bufexamac and hydrocortisone on the ileal responses, but not those of tetrodotoxin and verapamil.
已对苯甲酰胺衍生物甲氧氯普胺（Mcp）对离体豚鼠回肠对透壁刺激的反应的影响进行了定量分析。Mcp（0.03微克/毫升及以上）可增强这些反应，但这种依赖于钙的效应并非浓度依赖性（高达30微克/毫升）。Mcp可拮抗去甲肾上腺素、多巴胺、普鲁卡因、三磷酸腺苷、丁苯羟酸和氢化可的松对回肠反应的抑制作用，但对河豚毒素和维拉帕米的抑制作用无拮抗效果。
