Carvalhas M L, Figueira M A
Arch Int Pharmacodyn Ther. 1979 Nov;242(1):35-43.
Pretreatment with phenobarbital enhanced digitoxin toxicity in guinea-pigs. In both male and female animals the LD50 was reduced by one half as compared to control animals. Plasma and bile concentrations were determined at 15, 30, 60 and 120 min after intraperitoneal administration of 3H digitoxin. Plasma from pretreated guinea-pigs always presented higher concentrations of non-metabolized digitoxin and lower amounts of water soluble metabolites than control animals. If these compounds are less active than the parent drug, the increased toxicity of digitoxin after pretreatment with the enzymatic inducer may be explained by inhibition of detoxication.
苯巴比妥预处理会增强豚鼠中洋地黄毒苷的毒性。与对照动物相比，雄性和雌性动物的半数致死剂量（LD50）都降低了一半。在腹腔注射3H洋地黄毒苷后15、30、60和120分钟测定血浆和胆汁浓度。预处理过的豚鼠血浆中未代谢洋地黄毒苷的浓度总是高于对照动物，而水溶性代谢物的量则低于对照动物。如果这些化合物的活性低于母体药物，那么用酶诱导剂预处理后洋地黄毒苷毒性增加可能是由于解毒作用受到抑制所致。
