关于二环己胺及相关胺类对大鼠输精管去甲肾上腺素反应具有增强作用的作用模式的研究。
Studies on the modes of action of dicyclohexylamine and related amines with a potentiating effect on noradrenaline responses in the rat vas deferens.
作者信息
Mottram D R, Hickman J A
出版信息
Arch Int Pharmacodyn Ther. 1979 Nov;242(1):50-8.
Previous studies have shown that dicyclohexylamine (DCHA) and related amines with saturated and unsaturated cyclic side-chains produce a potentiation of noradrenaline responses in rat vas deferens. The present study shows that the potentiation is mediated via a cocaine-like effect, by acting as neuronal uptake inhibitors on sympathetic nerve terminals of the rat vas deferens. Furthermore, it has been established that the contractions of the vas, which are induced by high concentrations of DCHA and its analogues, are due to an indirect sympathomimetic activity of these compounds.
先前的研究表明，二环己胺（DCHA）以及具有饱和和不饱和环状侧链的相关胺类会增强大鼠输精管中去甲肾上腺素的反应。本研究表明，这种增强作用是通过类似可卡因的效应介导的，即作为大鼠输精管交感神经末梢的神经元摄取抑制剂起作用。此外，已经确定，高浓度的DCHA及其类似物诱导的输精管收缩是由于这些化合物的间接拟交感神经活性。
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