从尿毒症患者尿液中分离出的“中分子物质”中的一种强效细胞增殖抑制剂。

A potent inhibitor of cell proliferation in "middle molecules" isolated from the urine of uremic patients.

作者信息

Navarro J, Gerlier D, Touraine J L, Later R, Contreras P, Dore J F, Traeger J

出版信息

Biomedicine. 1979 Dec;31(9-10):261-4.

Abstract

A potent inhibitor of cell proliferation was found in the urine of a patient with chronic renal failure. This substance included in "middle molecules" (MM) fraction, was obtained by chromatography. This factor was shown to inhibit noticeably the proliferation of various cells : lymphocytes stimulated by allogeneic cells, monolayer cell lines of normal or tumorous origin and leukemic cell lines derived from acute lymphoblastic leukemia. This effect was reversible and thus could not be related to a direct, rapid cytotoxic effect of MM. Such substances could play an important part in uremic symptoms, such as immunodeficiency, anemia, thrombopenia, gastrointestinal or skin manifestations.

摘要

在一名慢性肾衰竭患者的尿液中发现了一种强效细胞增殖抑制剂。这种物质包含在“中分子”（MM）组分中，通过色谱法获得。该因子被证明能显著抑制多种细胞的增殖：同种异体细胞刺激的淋巴细胞、正常或肿瘤来源的单层细胞系以及急性淋巴细胞白血病衍生的白血病细胞系。这种作用是可逆的，因此不可能与MM的直接快速细胞毒性作用有关。这类物质可能在尿毒症症状中起重要作用，如免疫缺陷、贫血、血小板减少、胃肠道或皮肤表现。