在某些致癌烷基芳基三氮烯存在下的微粒体联苯2-羟基化作用。

Microsomal biphenyl 2-hydroxylation in the presence of some carcinogenic alkylaryltriazenes.

作者信息

McPherson F, Kolar G F

出版信息

Cancer Lett. 1979 Jan;6(1):33-8. doi: 10.1016/s0304-3835(79)80017-8.

Abstract

A hepatic mixed-function oxygenase system gave enhanced biphenyl 2-hydroxylation in the presence of known carcinogens in vitro and was therefore suggested as a convenient short-term assay for the detection of potentially dangerous compounds. However, the test did not yield the expected increase of biphenyl 2-hydroxylation with any of 8 selected carcinogenic triazenes. The new data are discussed in relation to the original supposition and to the hydroxylation pattern of various triazene substrates in vivo.

摘要

肝混合功能氧化酶系统在体外已知致癌物存在的情况下，对联苯2 - 羟化作用有增强作用，因此被提议作为一种检测潜在危险化合物的便捷短期检测方法。然而，该检测方法对8种选定的致癌三氮烯中的任何一种都未产生预期的联苯2 - 羟化作用增强。结合最初的假设以及各种三氮烯底物在体内的羟化模式对新数据进行了讨论。