红细胞生成性原卟啉病。IV. 防晒
Erythropoietic protoporphyria. IV. Protection from sunlight.
作者信息
Fusaro R M, Runge W J
出版信息
Br Med J. 1970 Mar 21;1(5698):730-1. doi: 10.1136/bmj.1.5698.730.
Abstract
Dihydroxyacetone and lawsone, in a vanishing cream base, applied to the skin was found to protect patients with erythropoietic protoporphyria against sunlight. The use of the same ingredients in a 50% isopropyl alcohol/water solution did not induce adequate light protection. The chemically induced ultraviolet light filter in the stratum corneum allowed these patients to change their lives from an "indoor" to an "outdoor" environment.
摘要
研究发现，将二羟基丙酮和紫铆因添加到雪花膏基质中涂抹于皮肤，可保护红细胞生成性原卟啉病患者免受阳光伤害。而在50%异丙醇/水溶液中使用相同成分，并未产生足够的光防护效果。角质层中化学诱导产生的紫外线滤光剂使这些患者能够从“室内”环境转变为“室外”环境，改变了他们的生活。
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引用本文的文献
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Effect of Simultaneous Administration of Dihydroxyacetone on the Diffusion of Lawsone Through Various In Vitro Skin Models.同时给予二羟基丙酮对指甲花醌透过各种体外皮肤模型扩散的影响。
AAPS PharmSciTech. 2015 Dec;16(6):1425-33. doi: 10.1208/s12249-015-0335-8. Epub 2015 May 19.
本文引用的文献
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ERYTHROPOIETIC PROTOPORPHYRIA. I. CLINICAL AND LABORABORY FEATURES IN SEVEN NEW CASES.红细胞生成性原卟啉症。一、7例新病例的临床和实验室特征
JAMA. 1965 Sep 20;193:1036-42. doi: 10.1001/jama.1965.03090120044011.
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Biophysical considerations of light protection.光防护的生物物理学考量
J Invest Dermatol. 1962 Nov;39:431-3.
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Clinical experience with a topical light filter.一种局部光过滤器的临床经验。
JAMA. 1962 Dec 15;182:1120-1. doi: 10.1001/jama.1962.03050500052015a.
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Erythropoietic protoporphyria: a family study.红细胞生成性原卟啉症：一项家族研究。
Br Med J. 1967 Mar 18;1(5541):659-63. doi: 10.1136/bmj.1.5541.659.
5
Sunlight protection in normal skin. By absorptive filter chemically induced in stratum corneum.正常皮肤的防晒。通过角质层中化学诱导的吸收性滤光片实现。
Arch Dermatol. 1966 Jan;93(1):106-11.
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