Schiller K F, Truelove S C, Williams D G
Br Med J. 1970 Apr 4;2(5700):7-14. doi: 10.1136/bmj.2.5700.7.
In a study of 2,149 emergency admissions because of haematemesis or melaena during a 15-year period, the sex ratio, age distribution, and main diagnostic groups showed no major change. Various factors affected the prognosis, such as the age of the patient, the underlying diagnosis, a low blood pressure on arrival at hospital, gross anaemia on arrival there, and the pattern of bleeding after admission. The fatality rate remained virtually constant throughout the period studied in spite of changes in diagnostic methods and management. There was a changing pattern in the type of operation performed in the treatment of bleeding peptic ulcer. Vagotomy combined with a drainage procedure and with a direct surgical attack on the bleeding point became more widely used at the expense of Polya or Billroth I partial gastrectomy and gave the best results. It is at first paradoxical that improved surgical results should not be reflected in a general improvement in the fatality rate, but this finding can be explained by the smaller proportion of patients treated by emergency surgery in the later years of the period studied. It is concluded that emergency surgery should be performed more frequently and that vagotomy plus drainage is the operation of choice in the peptic ulcer group.
在一项针对15年间因呕血或黑便而急诊入院的2149例患者的研究中,性别比例、年龄分布及主要诊断类别均未出现重大变化。多种因素会影响预后,如患者年龄、潜在诊断、入院时低血压、入院时严重贫血以及入院后出血模式等。尽管诊断方法和治疗手段有所改变,但在所研究的整个期间内病死率基本保持不变。在治疗出血性消化性溃疡时所采用的手术类型呈现出变化趋势。迷走神经切断术联合引流手术以及对出血点进行直接手术干预的应用越来越广泛,而波利亚或毕罗Ⅰ式胃部分切除术的应用则相应减少,且前者效果最佳。起初看似矛盾的是,手术效果的改善并未体现在病死率的普遍降低上,但这一发现可以通过在所研究期间后期接受急诊手术的患者比例较小来解释。研究得出结论,应更频繁地进行急诊手术,并且迷走神经切断术加引流术是消化性溃疡组的首选手术方式。