Danowski T S
Postgrad Med J. 1970 Mar;46(533):125-30. doi: 10.1136/pgmj.46.533.125.
Temporary stress-induced undue hyperglycaemia following an oral carbohydrate load taken during hospitalization is being tested as a possible indicator of prediabetes. Observations in patients 15 months after hospitalization have permitted us to compare the blood sugar, insulin and growth hormone patterns evoked by an oral glucose load before and after glucose intolerance has appeared, viz. to speculate upon the evolution of diabetes from prediabetes. Though the numbers of such instances are as yet limited, they already suggest several possible sequences. Thus, our data support the concept that glucose intolerance, in addition to stemming from a decrease in insulin levels, can develop with true increases or with no evident decrease in the insulin responses to oral glucose. The simplified in-hospital carbohydrate tolerance test employed in assembling groups of possibly prediabetic individuals is also an efficient means of detecting permanent glucose intolerance of the diabetes mellitus type.
住院期间口服碳水化合物负荷后因暂时应激导致的过度高血糖正作为糖尿病前期的一种可能指标进行测试。对患者住院15个月后的观察使我们能够比较在葡萄糖不耐受出现之前和之后口服葡萄糖负荷所引发的血糖、胰岛素和生长激素模式,即推测糖尿病从糖尿病前期的演变情况。尽管此类情况的数量目前仍然有限,但它们已经提示了几种可能的发展过程。因此,我们的数据支持这样一种观点,即葡萄糖不耐受除了源于胰岛素水平降低外,在对口服葡萄糖的胰岛素反应真正增加或没有明显降低的情况下也可能发生。在收集可能患有糖尿病前期个体的群体时所采用的简化住院期间碳水化合物耐量试验也是检测糖尿病类型永久性葡萄糖不耐受的一种有效方法。