采用各种手术去神经方法后心脏活动的损害。
Impairment of heart action following various methods of surgical denervation.
作者信息
Otto T J, Cheah P C
出版信息
Thorax. 1970 Mar;25(2):199-206. doi: 10.1136/thx.25.2.199.
Surgical cardiac denervation was carried out in 25 greyhounds and their responses to exercise, propranolol, and atropine were observed between one and three months afterwards. Our experiments confirm that a denervated heart shows delayed and diminished response to exercise and no response to atropine and propranolol. We found that no cardio-circulatory mechanism seems to be present in the cavae and that hearts can be `selectively' denervated to produce an isolated increase in right ventricular pressure which is presumably due to severance of inhibitory fibres leading to the right ventricle, so that the augmentory fibres are unopposed.
对25只灵缇犬进行了心脏手术去神经支配，并在术后1至3个月观察它们对运动、普萘洛尔和阿托品的反应。我们的实验证实，去神经支配的心脏对运动的反应延迟且减弱，对阿托品和普萘洛尔无反应。我们发现腔静脉中似乎不存在任何心循环机制，并且心脏可以“选择性”去神经支配，从而使右心室压力单独升高，这可能是由于通向右心室的抑制性纤维被切断，使得增强性纤维不受对抗。
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