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着色性干皮病患者皮肤中DNA合成缺陷的体内研究显示。

Defect in DNA synthesis in skin of patients with xeroderma pigmentosum demonstrated in vivo.

作者信息

Epstein J H, Fukuyama K, Reed W B, Epstein W L

出版信息

Science. 1970 Jun 19;168(3938):1477-8. doi: 10.1126/science.168.3938.1477.

DOI:10.1126/science.168.3938.1477
PMID:5445941
Abstract

Exposure of normal human skin in vivo to ultraviolet irradiation at wavelengths shorter than 320 nanometers stimtulated an unscheduled DNA synthesis in all of the cell layers of the epidermis and in the upper dermnial fibrocytes. The skin of patients with xeroderma pigmentosum did not show this response. correlation of these findings with previous tissue culture studies suggests that the defect in repair of the damaged DNA in xeroderma cells occurs in vivo as well as in vitro.

摘要

在体内，将正常人的皮肤暴露于波长小于320纳米的紫外线照射下，会刺激表皮所有细胞层以及真皮上层纤维细胞中出现非定标性DNA合成。着色性干皮病患者的皮肤未表现出这种反应。这些发现与先前的组织培养研究结果相关联，表明着色性干皮病细胞中受损DNA修复缺陷在体内和体外都会发生。

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1
Defect in DNA synthesis in skin of patients with xeroderma pigmentosum demonstrated in vivo.着色性干皮病患者皮肤中DNA合成缺陷的体内研究显示。
Science. 1970 Jun 19;168(3938):1477-8. doi: 10.1126/science.168.3938.1477.
2
DNA synthesis in normal and xeroderma pigmentosum fibroblasts following treatment with 8-methoxypsoralen and long wave ultraviolet light.用8-甲氧基补骨脂素和长波紫外线处理后正常及着色性干皮病成纤维细胞中的DNA合成
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New form of molecular defect in xeroderma pigmentosum.着色性干皮病分子缺陷的新形式。
Nature. 1970 Oct 24;228(5269):361-2. doi: 10.1038/228361a0.
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Relationship of DNA repair to carcinogenesis in xeroderma pigmentosum.着色性干皮病中DNA修复与致癌作用的关系。
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Xeroderma pigmentosum epidermal cells with normal UV-induced thymidine incorporation.具有正常紫外线诱导胸苷掺入的着色性干皮病表皮细胞。
J Invest Dermatol. 1972 Nov;59(5):402-8. doi: 10.1111/1523-1747.ep12627528.
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Xeroderma pigmentosum: abnormal monochromatic action spectrum and autoradiographic studies.着色性干皮病：异常单色作用光谱及放射自显影研究
J Invest Dermatol. 1971 Apr;56(4):281-6. doi: 10.1111/1523-1747.ep12261015.
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Repair of alkylation damage in ultraviolet-sensitive (xeroderma pigmentosum) human cells.紫外线敏感型（着色性干皮病）人类细胞中烷基化损伤的修复
Mutat Res. 1971 Aug;12(4):453-62. doi: 10.1016/0027-5107(71)90095-9.
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Prolonged ultraviolet-induced thymidine incorporation into xeroderma pigmentosum lymphocytes: studies on its duration, amount, localization and relationship to hydroxyurea.紫外线诱导的胸苷长时间掺入着色性干皮病淋巴细胞：关于其持续时间、量、定位以及与羟基脲关系的研究
Biochim Biophys Acta. 1972 Aug 16;277(1):7-14. doi: 10.1016/0005-2787(72)90345-0.
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Xeroderma pigmentosum: a human disease in which an initial stage of DNA repair is defective.着色性干皮病：一种人类疾病，其DNA修复的初始阶段存在缺陷。
Proc Natl Acad Sci U S A. 1969 Jun;63(2):428-35. doi: 10.1073/pnas.63.2.428.
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Unscheduled DNA synthesis, u.v.-induced chromosome aberrations and SV 40 transformation in cultured cells from xeroderma pigmentosum.着色性干皮病培养细胞中的非预定DNA合成、紫外线诱导的染色体畸变及SV40转化
Ann Hum Genet. 1971 Oct;35(2):149-60. doi: 10.1111/j.1469-1809.1956.tb01387.x.

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Mol Biol Cell. 2015 Nov 15;26(23):4183-6. doi: 10.1091/mbc.E15-04-0246.
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Photochem Photobiol. 2015 Mar-Apr;91(2):452-9. doi: 10.1111/php.12345. Epub 2015 Jan 8.
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Shining a light on xeroderma pigmentosum.揭示着色性干皮病的奥秘。
J Invest Dermatol. 2012 Mar;132(3 Pt 2):785-96. doi: 10.1038/jid.2011.426. Epub 2012 Jan 5.
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