测定异烟肼乙酰化酶表型的简单方法。
Simple method for determining isoniazid acetylator phenotype.
作者信息
Russell D W
出版信息
Br Med J. 1970 Aug 8;3(5718):324-5. doi: 10.1136/bmj.3.5718.324.
Abstract
Methods have been developed for estimating acetylisoniazid and isoniazid in urine without a spectrophotometer. In experiments with volunteers the ratio of acetylisoniazid to isoniazid in urine samples collected the morning after three spaced oral doses each of 100 mg. was bimodally distributed.
摘要
已经开发出在不使用分光光度计的情况下估算尿液中乙酰异烟肼和异烟肼的方法。在对志愿者进行的实验中，在分三次间隔口服每次100毫克后次日早晨收集的尿液样本中，乙酰异烟肼与异烟肼的比例呈双峰分布。
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本文引用的文献
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THE RELATIONSHIP BETWEEN THE CAPACITIES OF HUMAN SUBJECTS TO ACETYLATE ISONIAZID, SULFANILAMIDE AND SULFAMETHAZINE.
Life Sci (1962). 1965 Jan;4:99-107. doi: 10.1016/0024-3205(65)90040-8.
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STUDIES ON PHARMACOGENETICS. I. THE ENZYMIC ACETYLATION OF ISONICOTINIC ACID HYDRAZIDE (INH).
Biochem Pharmacol. 1964 Dec;13:1671-5. doi: 10.1016/0006-2952(64)90221-7.
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HUMAN ACETYLATION POLYMORPHISM.人类乙酰化多态性
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Genetic control of isoniazid metabolism in man.人体中异烟肼代谢的遗传控制。
Br Med J. 1960 Aug 13;2(5197):485-91. doi: 10.1136/bmj.2.5197.485.
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Comparison of isoniazid concentrations in the blood of people of Japanese and European descent; therapeutic and genetic implications.日本和欧洲血统人群血液中异烟肼浓度的比较；治疗及遗传学意义
Am Rev Tuberc. 1958 Dec;78(6):944-8. doi: 10.1164/artpd.1958.78.6.944.
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Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis.人体内异烟肼的代谢与周围神经炎发生的关系。
Am Rev Tuberc. 1954 Aug;70(2):266-73. doi: 10.1164/art.1954.70.2.266.
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Method for the estimation of acetylisoniazid in urine.
Tubercle. 1968 Jun;49(2):210-6. doi: 10.1016/0041-3879(68)90023-8.
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Rapid determination of isonicotinic acid hydrazide in whole blood with 2,4,6-trinitrobenzenesulphonic acid.
Clin Chim Acta. 1970 Mar;27(3):513-20. doi: 10.1016/0009-8981(70)90306-2.
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