Clarke D B, Neligan M C
Thorax. 1970 May;25(3):290-3. doi: 10.1136/thx.25.3.290.
In nine dogs submitted to a severe myocardial ischaemic challenge, multiple prosthetic implants running from the descending aorta to myocardial tunnels were successful in sustaining effective ventricular contraction for a mean period of 27 minutes. A control series of five dogs and five animals, in which the prostheses clotted, developed ventricular fibrillation within six minutes of the ligation of either the left or both coronary arteries. It is suggested that these findings, although not applicable to clinical practice, should stimulate further investigation into the surgical support of the acutely ischaemic myocardium.
在9只接受严重心肌缺血挑战的犬中，多个从降主动脉延伸至心肌隧道的假体植入成功维持了有效的心室收缩，平均时长为27分钟。在5只犬和5只动物的对照系列中，假体发生凝血，在结扎左冠状动脉或双侧冠状动脉后的6分钟内出现了心室颤动。研究表明，这些发现虽然不适用于临床实践，但应激发对急性缺血心肌外科支持的进一步研究。
