Cockett A T, Al-Juburi A, Altebarmakian V, Vergamini R F, Caldamone A A
Trans Am Assoc Genitourin Surg. 1979;71:47-9.
A number of reports have shown that serotonin has a detrimental effect on spermatogenesis and androgen synthesis. Serotonin has 2 mechanisms of action on the testicle: 1) vasoconstrictive changes and 2) direct alterations of testicular metabolism and endocrine activity. The data in animals with the experimental varicocele clearly mimic the human situation. All of the seminal parameters except volume are decreased after creating the varicocele. In many infertile patients with a varicocele serotonin may be the inciting factor that results in subfertile semen parameters. This is corroborated by the presence of elevated serotonin levels in spermatic vein plasma of certain patients with a varicocele. More data comparing the relationship between spermatic vein and peripheral blood serotonin levels in patients with and without a varicocele are needed. This investigation also is being pursued in patients undergoing inguinal operations for lesions other than a varicocele.
多项报告表明，血清素对精子发生和雄激素合成具有有害作用。血清素对睾丸有两种作用机制：1）血管收缩变化；2）睾丸代谢和内分泌活动的直接改变。实验性精索静脉曲张动物的数据清楚地模拟了人类的情况。制造精索静脉曲张后，除精液量外的所有精液参数均下降。在许多患有精索静脉曲张的不育患者中，血清素可能是导致精液参数低下的诱发因素。某些精索静脉曲张患者的精索静脉血浆中血清素水平升高证实了这一点。需要更多数据来比较有和没有精索静脉曲张的患者精索静脉和外周血血清素水平之间的关系。对因非精索静脉曲张病变接受腹股沟手术的患者也正在进行这项研究。
